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目的 探讨CD31和D2-40在同时性结直肠癌腹膜转移患者中的表达情况及二者的相关性.方法 采用免疫组织化学MaxVision法检测59例(其中伴腹膜转移者19例,不伴腹膜转移者40例)结直肠癌组织中CD31和D2-40蛋白表达情况.结果 ①伴或不伴腹膜转移结直肠癌组织中CD31和D2-40蛋白表达阳性率均明显高于正常结肠组织(P＜0.05),但二者在伴或不伴腹膜转移结直肠癌组织间比较的差异均无统计学意义(P＞0.05).②CD31微血管密度和D2-40微淋巴管密度在伴腹膜转移结直肠癌组织中均明显高于正常结肠组织(P＜0.05)和不伴腹膜转移结直肠癌组织(P＜0.05).③CD31微血管密度和D2-40微淋巴管密度与不伴腹膜转移结直肠癌患者的所有临床病理特征均无关(P＞0.05);但二者在伴腹膜转移的中低分化腺癌及黏液和印戒细胞癌中均明显高于其他类型(P＜0.05),而与其性别、年龄及肿瘤直径均无关(P＞0.05).④在伴或不伴腹膜转移结直肠癌组织中CD31微血管密度和D2-40微淋巴管密度呈正相关(r=0.342,P=0.012;r=0.119,P=0.008).结论 在结直肠癌伴腹膜转移组织中的CD31微血管密度和D2-40微淋巴管密度均高于不伴腹膜转移者,且二者呈正相关,结果提示其与腹膜转移有一定的关系,并且可能存在某些共同调控的方式协同参与结直肠癌腹膜转移的发生.“,”Objective To detect expressions of CD31 and D2-40 in patients with simultaneous colorectal cancer with peritoneal metastasis and investigate their correlation between them.Method The expressions of CD31 and D2-40 protein in these 59 cases (there were 19 and 40 patients with or without peritoneal metastasis,respectively) of colorectal cancer were detected by immunohistochemical MaxVision method.Results ① The positive rates of CD31 and D2-40 protein expression in the colorectal cancer tissues with or without peritoneal metastasis were significantly higher than those of the normal colonic tissues (P＜0.05),but which had no significant differences between the colorectal cancer tissues with or without peritoneal metastasis (P＞0.05).② The CD31 microvessel density (CD31-MVD) and D2-40 lymphatic microvessel density (D2-40-LMVD) in the colorectal cancer tissues with peritoneal metastasis were significantly higher than those of the normal colonic tissues (P＜0.05) and the colorectal cancer tissues without peritoneal metastasis (P＜0.05).③ The CD31-MVD and D2-40-LMVD were not associated with all the clinicopathologic characteristics of the colorectal cancer patients without peritoneal metastasis (P＞0.05),but which in the poorly differentiated adenocarcinoma and mucinous and signet ring cell carcinomas patients with peritoneal metastasis were significantly higher than those of the other types (P＜0.05) and were not associated with the age,gender,and diamter of the tumor of it (P＞0.05).④ There was a positive correlation between the CD31-MVD and the D2-40-LMVD in the colorectal cancer patients with or without peritoneal metastasis (r=0.342,P=0.012;r=0.119,P=0.008).Conclusions CD31-MVD and D2-40-LMVD in colorectal cancer patients with peritoneal metastasis highly express and has a positive correlation,which means that they might have a certain relationship with peritoneal metastasis.There may be some common regulation way and collaboratively participate peritoneal metastasis of colorectal cancer.