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目的:评价有关骨桥蛋白(OPN)在卵巢癌组织中表达的情况及与卵巢癌不同临床病理特征的关系。方法:系统检索NCBI PubMed、EMBASE、维普、万方数据库中截止2013年11月符合纳入标准的国内外公开发表的有关OPN在卵巢癌组织中表达的文献7篇,通过固定效应模型综合分析合并效应量,采用RevMan 5.1统计软件进行分析。结果:Meta分析显示,OPN在卵巢癌组和正常卵巢组表达差异有统计学意义[OR=20.24,95%CI(9.66,42.43),P<0.000 01]。OPN在卵巢癌组和良性卵巢组表达差异有统计学意义[OR=16.58,95%CI(9.60,28.64),P<0.000 01]。OPN在卵巢癌高分化组和中低分化组表达的差异有统计学意义[OR=0.16,95%CI(0.08,0.32),P<0.000 01]。OPN在卵巢癌临床Ⅰ-Ⅱ期组和临床Ⅲ-Ⅳ期组表达的差异有统计学意义[OR=0.16,95%CI(0.09,0.29),P<0.000 01]。OPN在卵巢癌淋巴结转移组和淋巴结未转移组表达的差异有统计学意义[OR=4.20,95%CI(2.24,7.88),P<0.000 01]。结论:OPN高表达与卵巢癌及其不同临床病理特征有显著相关性。但受纳入文献质量影响,还需进一步用国内外高质量的研究来证实。
OBJECTIVE: To evaluate the expression of osteopontin (OPN) in ovarian cancer and its relationship with different clinicopathological features of ovarian cancer. Methods: Seven published literatures about OPN expression in ovarian cancer tissues that meet the inclusion criteria in NCBI PubMed, EMBASE, VIP, Wanfang database as of November 2013 were systematically searched, and the combined effects were comprehensively analyzed by the fixed effects model Volume, using RevMan 5.1 statistical software for analysis. Results: Meta-analysis showed that OPN expression in ovarian cancer group and normal ovary group was significantly different [OR = 20.24,95% CI (9.66,42.43), P <0.000 01]. OPN expression in ovarian cancer group and benign ovarian group was significantly different [OR = 16.58,95% CI (9.60,28.64), P <0.000 01]. There was significant difference in the expression of OPN in well-differentiated and moderately-differentiated ovarian cancers [OR = 0.16, 95% CI (0.08,0.32), P <0.000 01]. OPN expression in ovarian cancer clinical stage Ⅰ-Ⅱ group and clinical stage Ⅲ-Ⅳ group was significantly different [OR = 0.16,95% CI (0.09,0.29), P <0.000 01]. The expression of OPN was significantly different between lymph node metastasis group and non-metastasis lymph node group [OR = 4.20, 95% CI (2.24, 7.88), P <0.000 01]. Conclusion: The high expression of OPN has significant correlation with ovarian cancer and its different clinicopathological features. However, influenced by the quality of the documents involved, further research needs to be done with high quality at home and abroad.