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[目的]寻找前列腺肿瘤组织与正常组织的差异表达蛋白。[方法]运用蛋白质组学的方法分析前列腺癌组织和正常组织蛋白表达谱的差异,通过双向电泳筛选差异蛋白,质谱鉴定。[结果]成功构建了前列腺组织的双向电泳图谱,并筛选出一个差异蛋白,该差异蛋白在17例(17/24,70.8%)前列腺癌组织中表达上调,仅在5例(5/24,20.8%)对照组中呈高表达,两者具有统计学差异(P=0.001)。经鉴定,该差异蛋白为促凋亡胱天蛋白酶衔接蛋白(PACAP)。[结论]促凋亡胱天蛋白酶衔接蛋白可以视作潜在的前列腺癌肿瘤标志物。
[Objective] To find differentially expressed proteins between prostate tumor tissues and normal tissues. [Method] Proteomics was used to analyze the differences of protein expression profiles between prostate cancer tissues and normal tissues. The two proteins were identified by two-dimensional electrophoresis and identified by mass spectrometry. [Results] The two-dimensional electrophoresis pattern of prostate tissue was successfully constructed and a differential protein was screened. The differential protein was up-regulated in 17 cases (17/24, 70.8%) of prostate cancer tissues, only in 5 cases (5/24, 20.8%) was high in the control group, with statistical difference (P = 0.001). The differential protein was identified as the pro-apoptotic caspase adapter protein (PACAP). [Conclusion] The pro-apoptotic caspase-like adapter protein can be considered as a potential tumor marker of prostate cancer.