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目的探讨不同程度基底动脉狭窄时基底动脉及其供血区脑组织血流动力学情况。方法选择经磁共振动脉血管成像(MRA)检查诊断为基底动脉狭窄、闭塞患者(狭窄组)19例,其中男性13例,女性6例;年龄37~80岁。对照组(基底动脉正常患者)16例,其中男性10例,女性6例;年龄37~69岁。所有患者均行颅脑MRA、快速电影相位对比及流动敏感交互式反转恢复序列检查,对图像进行后处理,得出流速并计算出流量。测量两侧枕叶、小脑、脑桥、延髓灌注值。对结果进行统计学分析。结果狭窄组与对照组间平均流速、峰值流速及血流量差异均有统计学意义(P<0.05),狭窄组狭窄以远处与对照组之间平均流速、峰值流速及血流量差异均有统计学意义(P<0.05)。狭窄组基底动脉供血区脑组织灌注总值较对照组低(P<0.05)。不同程度基底动脉狭窄者灌注流量间差异有统计学意义(P<0.05)。不同程度基底动脉狭窄者基底动脉狭窄以远处平均流速、峰值流速、血流量间差异均有统计学意义(P<0.05)。不同程度基底动脉狭窄者后循环供血区脑组织灌注值间差异无统计学意义(P<0.05)。狭窄处基底动脉血流量与基底动脉狭窄程度呈负相关(r=-0.70,P<0.05)。结论随着基底动脉狭窄程度的加重,狭窄处基底动脉血流量减低。
Objective To investigate the hemodynamics of brain tissue in basilar artery and its donor area with different degrees of basilar artery stenosis. Methods Nineteen patients with stenosis and occlusion of the basilar artery (stenosis group) were diagnosed by magnetic resonance angiography (MRA). Among them, 13 were males and 6 were females; their ages ranged from 37 to 80 years. Control group (normal basilar artery patients) 16 cases, including 10 males and 6 females; aged 37 to 69 years. All patients underwent brain MRA, fast contrast phase contrast and flow-sensitive interactive inversion recovery sequence examination, post-processing the image to obtain the flow rate and calculate the flow rate. Measurement of occipital lobe, cerebellum, pons, medulla oblongata perfusion value. The results were statistically analyzed. Results There were significant differences in mean flow rate, peak flow rate and blood flow between the stenosis group and the control group (P <0.05). There was statistical difference between the stenosis group and the control group in average flow velocity, peak flow velocity and blood flow volume Significance (P <0.05). The stenosis group of basilar artery blood supply area brain perfusion lower than the control group (P <0.05). There were significant differences in perfusion flow between patients with different degrees of basilar artery stenosis (P <0.05). Basement artery stenosis in patients with different degrees of basilar artery stenosis were statistically significant at distant mean flow velocity, peak velocity and blood flow (P <0.05). There was no significant difference in the perfusion values of cerebral blood flow in patients with different degrees of basilar artery stenosis (P <0.05). The basilar artery blood flow in stenosis was negatively correlated with the degree of basilar artery stenosis (r = -0.70, P <0.05). Conclusions As the degree of basilar artery stenosis aggravates, the basilar artery blood flow in the stenosis decreases.