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全反式维甲酸（ａｌｌ－ｔｒａｎｓ－ｒｅｔｉｎｏｉｃａｃｉｄ，ＡＴＲＡ）用于治疗急性早幼粒细胞白血病及皮肤病。由于该药不稳定，半衰期短且副作用较大，如引起高脂血症［１］、高颅压综合征［２］、高白细胞综合征［３］、维甲酸综合征［４］等。因此，我们将其做成缓释
All-trans-retinoic acid (ATRA) is used in the treatment of acute promyelocytic leukemia and dermatosis. As the drug is unstable, short half-life and greater side effects, such as causing hyperlipidemia [1], intracranial hypertension syndrome [2], high leukocyte syndrome [3], retinoic acid syndrome [4] and so on. Therefore, we will make it a sustained release