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胃粘膜组织和细胞癌变时在超微结构、形态、功能上都发生变化;特别是酶类更能较敏感地反映这一变化,成为肿瘤生化的重要标记物。传统上胃癌的临床诊断主要依靠上消化道钡餐X线摄片、胃镜和脱落细胞检查等方法,但总有一部分患者因假阴性而延误诊断。不少学者相继研究生化检测方法,迄今为止已发现胃癌患者胃液中某些酶的活性增高,如乳酸脱氢酶(LDH)、β-葡萄糖醛酸酶、谷草转氨酶、醛缩酶、磷酸己糖异构酶、碱性磷酸酶(AKP)、异
Changes in the ultrastructure, morphology, and function of gastric mucosal tissue and cell cancerous changes; in particular, enzymes can more sensitively reflect this change and become an important biomarker for tumor biochemistry. Traditionally, the clinical diagnosis of gastric cancer mainly relies on the upper gastrointestinal barium meal X-ray, gastroscopy and exfoliated cell examination methods, but there are always patients with delayed diagnosis due to false negatives. Many scholars have successively performed postgraduate testing methods. Up to now, it has been found that the activities of certain enzymes in the gastric juice of patients with gastric cancer are increased, such as lactate dehydrogenase (LDH), β-glucuronidase, aspartate aminotransferase, aldolase, and hexose phosphate. Isomerase, alkaline phosphatase (AKP), iso