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75例上消化道出血病人,随机分为两组:洛赛克(20mgqd)组41例,雷尼替丁(100mg iv bid)组34例。洛赛克组止血的显效率和总有效率分别为78.1％和97.6％,雷尼替丁组则分别为41.2％和82.4％。洛赛克组治疗3天和5天后胃内pH分别升为6.10±1.03和6.34±1.01,雷尼替丁组分别为2.88±0.57和3.10±0.48。洛赛克组的BAO抑制率在3天和5天后分别为93.3％与94.1％,雷尼替丁组分别为51.5％与60.4％。当胃内pH>6时,止血效果增加。洛赛克对上消化道出血的止血效果和胃酸抑制均优于雷尼替丁。
75 patients with upper gastrointestinal bleeding were randomly divided into two groups: 41 in the Losec (20 mgqd) group and 34 in the 100 mg iv bid group. The effective rate and total effective rate of hemostasis in the Losec group were 78.1% and 97.6%, respectively, while those in the ranitidine group were 41.2% and 82.4%, respectively. After 3 days and 5 days of treatment, the intragastric pH in the Losec group increased to 6.10 ± 1.03 and 6.34 ± 1.01, respectively, while that in the ranitidine group was 2.88 ± 0.57 and 3.10 ± 0.48, respectively. BAO inhibition rates in the Losec group were 93.3% and 94.1% after 3 days and 5 days, respectively, and 51.5% and 60.4% in the ranitidine group, respectively. When the stomach pH> 6, the hemostatic effect increases. Losec’s hemostatic effect on gastric upper gastrointestinal bleeding and gastric acid suppression are better than ranitidine.