当今美国使用的四个HMG－COA还原酶抑制剂为洛伐他汀、普伐他汀、塞伐他汀和氟伐他订。这些药物的化学结构相似，但亲脂性彼此不同，其临床意义还有争论。426例成年男性原发性高胆固醇血症（Ⅱa和Ⅱb型高脂蛋白血症）患者。随机口服洛伐他订40mg每晚1次（211例）或普伐他汀40mg The four HMG-COA reductase inhibitors currently used in the U.S. are lovastatin, pravastatin, simvastatin and fluvastatin. The chemical structure of these drugs is similar, but lipophilic different from each other, its clinical significance is still controversial. 426 adult male patients with primary hypercholesterolemia (type IIa and type IIb hyperlipoproteinemia) patients. Randomized oral lovastatin 40mg once night (211 cases) or pravastatin 40mg