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目的调查湖北省武穴地区慢性乙型肝炎患者白细胞介素-1β基因(IL-1β)第5号外显子(+3953C/T)位点基因多态性的分布及其相关性。方法采用聚合酶链反应-限制性片段长度多态性的分析方法,检测了360例慢性乙型肝炎患者和340例健康对照者IL-1β(+3953 C/T)位点基因多态性,计算并分析其基因型和等位基因频率。结果在病例组和健康对照组,IL-1β(+3953 C/T)位点基因型的分布以CC型最为多见,CT型次之,没有发现TT型,C等位基因频率明显偏高,T等位基因频率明显偏低;在不同性别之间无显著性差异(P>0.05);其基因型及等位基因的分布在病例组和对照组间无显著性差异(P>0.05)。结论在湖北省武穴地区,IL-1β(+3953 C/T)位点碱基突变率极低,其基因型及等位基因型的分布不存在性别之间的区别,与慢性乙型肝炎病程不存在相关性。
Objective To investigate the distribution and correlation of polymorphism of exon 5 (+ 3953C / T) in interleukin-1β (IL-1β) gene in patients with chronic hepatitis B in Wuxue area of Hubei province. Methods Polymorphisms of IL-1β (+3953 C / T) gene in 360 patients with chronic hepatitis B and 340 healthy controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Calculate and analyze its genotype and allele frequency. Results The distribution of genotypes of IL-1β (+3953 C / T) locus was the most common in CC group and CT genotype in case group and healthy control group. TT genotype was not found, and the frequency of C allele was significantly higher (P> 0.05). There was no significant difference in the distribution of genotypes and alleles between the case group and the control group (P> 0.05) . Conclusion The mutation rate of IL-1β (+3953 C / T) is extremely low in Wuxue area of Hubei Province. There is no gender difference between genotypes and alleles. There is no correlation between the course of the disease.