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目的 研究右佐匹克隆对老年痴呆患者睡眠障碍治疗前后状态改善的临床观察分析.方法 收集2016年8月至2018年8月大连大学附属新华医院诊治的老年痴呆症患有睡眠障碍的患者84例,随机分为观察组和对照组,每组42例.观察组患者以右佐匹克隆片口服,对照组患者以阿普唑仑片口服.采用匹兹堡睡眠质量指数(PSQI)量表系统评估两组患者药物治疗前后的睡眠状态改善情况.结果 观察组患者药物治疗后2、4周的睡眠障碍状态改善总有效率显著高于对照组的总有效率[78.57％(33/42)比54.76％(23/42)、92.86％ (39/42)比73.81％(31/42)](P＜0.05),而且PSQI量表评估分值结果也显著优于对照组(P＜0.05).结论 右佐匹克隆治疗有助于老年痴呆症患者睡眠障碍状态的改善,临床上应用价值较高.“,”Objective To observe and analyze rightzopiclone on the improvement of sleep disorders in patients with Alzheimer disease.Methods Eighty-four Alzheimer disease patients with sleep disorders admitted to the Department of Neurology of the Dalian University Affiliated Xinhua Hospital from August 2016 to August 2018 were selected and randomly divided into observation group and control group,with 42 patients in each group.The patients in the observation group were given rightzopiclone orally,while the patients in the control group were given alprazolam orally.The Pittsburgh Sleep Quality Index (PSQI) was applied to assess the sleep state of the two groups before and after the treatment.Results The total effective rates of sleep improvement in the observation group were 78.57％and 92.86％ after 2 and 4 weeks of the treatment,which was significantly higher than that in the control group of 54.76％ and 73.81％ (P ＜ 0.05),and the PSQI assessment results were also significantly better than those in the control group (P＜0.05).Conclusions Rightzopiclone is helpful for the improvement of sleep state of Alzheimer disease patients with sleep disorders,and it has high clinical application value.