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目的探讨冠心病患者乙醛脱氢酶(ALDH)2基因单核苷酸多态性与硝酸甘油疗效以及 ALDH2对饮酒面红的影响。方法选择经冠状动脉(冠脉)造影主要冠脉分支狭窄>50%患者142例,依据饮酒是否面红分为无面红组88例,面红组54例。检测 ALDH2基因单核苷酸多态性,依心绞痛缓解程度和时间判断患者硝酸甘油疗效。比较两组 ALDH2基因型分布及硝酸甘油疗效差异和关系,最终评价三者之间的相关性。结果饮酒无面红组患者 ALDH2*1分布、硝酸甘油有效率及迅速起效率均显著高于面红组(P<0.01),ALDH2*1患者硝酸甘油有效率及迅速起效率显著高于ALDH2*2患者(P<0.01)。结论 ALDH2基因单核苷酸多态性与饮酒是否面红及硝酸甘油治疗心绞痛疗效相关,饮酒无面红的冠心病患者硝酸甘油有效率较高,可能与 ALDH2*1酶活性高有关。
Objective To investigate the effect of single nucleotide polymorphism of ALDH 2 gene, nitroglycerin and ALDH2 on drinking redness in patients with coronary heart disease. Methods 142 patients with coronary artery stenosis (> 50%) undergoing coronary artery angiography were divided into two groups according to whether the drink redness was classified as non-redness group (88 cases) or red-face group (54 cases). ALDH2 gene single nucleotide polymorphisms detected, according to the degree of angina pectoris and time to determine the efficacy of nitroglycerin in patients. The distribution of ALDH2 genotypes and the differences in the efficacy of nitroglycerin between the two groups were compared, and the correlation between the three was finally evaluated. Results ALDH2 * 1 distribution, nitroglycerin efficiency and rapid onset efficiency were significantly higher in patients without alcohol redness (P <0.01). The efficiency and rapid onset of nitroglycerin in ALDH2 * 1 patients were significantly higher than those in ALDH2 * 2 patients (P <0.01). Conclusions Single nucleotide polymorphism of ALDH2 gene is correlated with the curative effect of nitroglycerin and nitroglycerin in the treatment of angina pectoris. Nitroglycerin is more effective in patients with coronary heart disease without alcohol redness, which may be related to the high ALDH2 * 1 enzyme activity.