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目的探讨己酮可可碱在胆管阻塞性大鼠肝纤维化模型中的抗纤维化作用。方法雄性SD大鼠60只,分为假手术组、肝纤维化模型组、己酮可可碱组。比较各组肝组织羟脯氨酸含量和组织学评分。结果己酮可可碱组组织评分为2.38分,较模型组(3.5分)显著下降(P﹤0.05)。羟脯氨酸含量模型组[(108.33±14.54)μg/ml]较假手术组[(15.58±4.25)μg/ml]显著升高(P﹤0.05),己酮可可碱组为[(67.50±12.48)μg/ml],与模型组比较下降38%。结论己酮可可碱在大鼠胆管阻塞性肝纤维化模型中具有一定的抗纤维化作用。
Objective To investigate the antifibrotic effect of pentoxifylline in a rat model of biliary obstruction of liver fibrosis. Methods Sixty male Sprague-Dawley rats were randomly divided into sham operation group, model group of hepatic fibrosis and pentoxifylline group. The hydroxyproline content and histological score of liver tissue in each group were compared. Results The pentoxifylline group had a tissue score of 2.38, which was significantly lower than that of the model group (3.5) (P <0.05). The hydroxyproline content in model group [(108.33 ± 14.54) μg / ml] was significantly higher than that in sham operation group [(15.58 ± 4.25) μg / ml] 12.48) μg / ml], a 38% decrease from the model group. Conclusion Pentoxifylline has a certain anti-fibrotic effect in rat model of biliary obstruction of liver fibrosis.