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动态观察28例急性心肌梗塞(AMI)患者血浆内皮素(ET)及血清肌红蛋白(Mb)水平的变化,并同时选择13倒不稳定心绞痛(UA)患者和15例健康人做为对照。结果表明,AMI组血中ET及Mb水平均于梗塞24小时之内达峰值,且随病程延长而逐渐下降,7天后降至正常范围,AMI组血浆ET水平显著高于UA组及正常组(P<0.01),其中UA组又明显高于正常组(P<0.01);相关分析显示AMI患者血浆ET水平与血清Mb水平呈正相关(r=0.5832,P<0.01)。提示血浆ET水平测定可做为监测AMI临床过程及估测心肌损害程度的一项指标。
The changes of plasma endothelin (ET) and serum myoglobin (Mb) level in 28 patients with acute myocardial infarction (AMI) were dynamically observed. The control group included 13 patients with unstable angina pectoris (UA) and 15 healthy controls. The results showed that the levels of ET and Mb in blood of AMI peaked within 24 hours after infarction and gradually decreased with the prolongation of the course of disease. After 7 days, the levels of ET and Mb dropped to the normal range. The plasma levels of ET in AMI group were significantly higher than those in UA group and normal group P <0.01), and the UA group was significantly higher than the normal group (P <0.01). The correlation analysis showed that the plasma ET level was positively correlated with the serum Mb level in AMI patients (r = 0.5832, P <0.01). It is suggested that the determination of plasma ET levels can be used as an indicator to monitor the clinical course of AMI and assess the extent of myocardial damage.