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在肝素钠生产实际中,测定肝素钠效价多采用羊血浆法。血浆凝固程度的判定则以美国药典羊血浆法五级凝固度为判定标准,而计算“1/2”级凝固度剂量(V_(CE(1/2)))的方法,均采用内插法。如美国药典采用的移动平均内插法,美国3M公司瑞克尔药厂采用的直接内插法。前者计算较繁,测定的结果较准确。后者计算简单,测定的结果误差较大,但在肝素钠生产实际中多乐于采用。为了减小误差,简便计算手续,经适当设计,即: (1)剂量排列按等差级数递增。
In the actual production of heparin sodium, sodium heparin titer is determined by the sheep plasma method. The degree of plasma coagulation was determined according to the fifth-order degree of solidification of the United States Pharmacopoeia Sheep’s plasma and the method of calculating the “1/2” level of coagulation dose (V_ (CE (1/2))) . Such as the United States Pharmacopoeia using moving average interpolation method, the United States 3M company Rickel pharmaceutical direct interpolation method. The former calculation is more complex, the determination of the results more accurate. The latter calculation is simple, the determination of the error of the larger, but in the production of heparin more than happy to use. In order to reduce the error, simple calculation procedures, the appropriate design, namely: (1) dose distribution by increasing the number of steps.