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对米非词酮多次用药后大鼠子代的生长发育、生殖毒性、遗传毒性以及形态变化等进行了研究。 SD大鼠雌雄合笼妊娠后 ,于妊娠第 7～ 9天 ,每天给米非司酮 4 mg/ kg(抗早孕剂量 ) ,以终止妊娠。两周后重复以上步骤 ,并终止第二次妊娠。然后每天给米非司酮 1 mg/ kg共 1 4天。再与雄鼠合笼 ,于确定妊娠当天开始 ,每天给米非司酮 0 .5mg/kg1 5天。至孕 2 0天 ,半数鼠解剖取材 ,余鼠产仔 ,观察各项指标。结果表明 ,米非司酮多次用药对大鼠胚胎的肝脏淋巴细胞染色体畸变率、微核率 ,以及幼鼠骨髓细胞姐妹染色单体互换率 (SCE) ,均未见明显的遗传学影响 ;出生的幼鼠生长发育良好 ,所测各项有关生殖毒性及形态变化指标与对照组无明显差异。本检测的结果显示 ,米非司酮不引起大鼠子代的遗传学改变。
The growth and development, reproductive toxicity, genotoxicity and morphological changes of rat offsprings after repeated use of mifepristone were studied. After the SD male and female cage pregnancy, in the first 7-9 days of gestation, mifepristone 4 mg / kg (anti-early pregnancy dose) to terminate the pregnancy. Repeat the above steps two weeks later and terminate the second pregnancy. Mifepristone (1 mg / kg) was given daily for 14 days. And then with the male mouse cages, to determine the beginning of the day of pregnancy, mifepristone 0.5 mg / kg1 5 days a day. 20 days pregnant, half of the rat anatomical material, more than a litter, observe the indicators. The results showed that there were no obvious genetic effects of multiple doses of mifepristone on the chromosome aberration rate, micronucleus rate of rat liver lymphocytes and sister chromatid exchange rate (SCE) of rat bone marrow cells ; Born baby rats grow well developed, the measured reproductive toxicity and morphological changes of indicators and the control group no significant difference. The results of this test show that mifepristone does not cause genetic changes in the offspring of rats.