Werner综合征是一种罕见的、常染色体隐性疾病,青年人的临床症状类似于老年人。它有时被称为“成年早老症”,但Werner 综合征与正常衰老过程有明显区别。近来有证据表明,Werner 综合征被认为是类似于着色性干皮病、毛细管扩张性共济失调、Fanconi 贫血和Bloom 综合征的染色体不稳定综合征。由于本病以常染色体隐性方式遗传,所以Werner 综合征可能是由单基因缺陷或小的多基因缺失引起的。因此,它提供了研究引起衰老部分表型摸拟的各种生物学和生化学结果的机会。了解Werner综合征的基本分子缺陷,可以深入了解衰老 Werner syndrome is a rare, autosomal recessive disease. The clinical symptoms in young people are similar to those in the elderly. It is sometimes referred to as “progressive adulthood,” but Werner syndrome is distinctly different from the normal aging process. There is recent evidence that Werner syndrome is considered a chromosomal instability syndrome similar to xeroderma pigmentosum, telangiectasia ataxia, Fanconi anemia, and Bloom syndrome. Because this disease is inherited in an autosomal recessive manner, Werner syndrome may be caused by a single gene defect or a small polygenic deletion. Therefore, it provides the opportunity to study various biological and biochemical results that cause the phenotypic phenotype of aging. Understand the basic molecular deficiencies of Werner Syndrome to gain insight into aging