类风湿性关节炎(RA)是一种慢性自身免疫性疾病,虽然其根本的病因尚不完全清楚,但炎性细胞因子表达的失调,黏附分子和基质金属蛋白酶的过度表达,滑膜成纤维细胞的大量增生等都是其发病的重要因素[1]。尽管目前用于关节炎治疗的药物较多,但传统的药物疗效不显著且不良反应大,新近 Rheumatoid arthritis (RA) is a chronic autoimmune disease, although its underlying cause is not yet fully understood, but dysregulation of inflammatory cytokines, overexpression of adhesion molecules and matrix metalloproteinases, synovial fibroblasts A large number of cell proliferation is an important factor in its incidence [1]. Although there are many drugs currently used for the treatment of arthritis, traditional drugs have no significant effect and the adverse reactions are large.