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肺巨噬细胞染上铅毒后在代谢、生化和免疫功能等方面均有改变。关于铅离子(pb~(2+)),对pAM免疫吞噬功能的影响,迄今国内外尚未见报导。Bendich曾用鸡红细胞(CRBC)观察pb~(2+)对pAM吞噬抑制作用,但由于正常pAM对CRBC的吞噬也不多(仅为2％),所以未能观察到pb~(2+)对pAM的吞噬抑制。 PAM表面有丰富的F_(?)和C_3受体,借助于这些受体,巨噬细胞可以大大地增强吞噬功能。在本实验验中,我们用致敏的CRBC做吞噬试验,以提高吞噬指数,从而较灵敏地反映出Pb~(2+)对吞噬的抑制作用。
After exposure to lead poisoning, lung macrophages have changed in metabolism, biochemistry, and immune function. With respect to lead ions (pb~(2+)), the effects of pAM immunophagy have not been reported at home and abroad. Bendich used chicken erythrocytes (CRBC) to observe the inhibition of pAM phagocytosis by pb 2+ , but since normal pAM phagocytosis of CRBC is not high (only 2%), pb 2+ cannot be observed. Phagocytic inhibition of pAM. There are abundant F_(?) and C_3 receptors on the surface of PAM. With these receptors, macrophages can greatly enhance phagocytosis. In this experiment, we used sensitized CRBCs to perform phagocytosis experiments to increase the phagocytic index, and thus more sensitively reflect the inhibitory effect of Pb 2+ on phagocytosis.