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目的 了解老年男性骨质疏松症患者骨密度和骨代谢生化指标变化的特点。 方法 对 30例老年男性骨质疏松症患者进行腰椎 (L2 4 )骨密度 (BMD)、骨矿含量 (BMC)、血和尿骨代谢生化指标的测定 ,并与对照组进行比较。 结果 骨质疏松 (OP)组的BMD和BMC均显著小于对照组 ,分别比对照组下降 2 1 6 %和 2 5 % ;OP组骨形成指标血清碱性磷酸酶 (ALP)和C端骨钙素 (BGP)明显高于对照组 ,分别上升 2 5 4%和 2 2 2 % ;骨吸收指标尿羟脯氨酸与肌酐的比值 (HOP/Cr)和I型胶原N 末端肽与肌肝的比值 (INTX/Cr)明显高于对照组 ,分别上升 2 2 6 %和 2 2 3 %。OP组血清T水平明显低于对照组 ,两组血清 2 5 羟维生素D3(2 5 OH D3)均在正常低限或低于正常水平。 结论 腰椎 (L2～ 4 )BMD和BMC是诊断男性骨质疏松症的主要依据 ;老年男性骨质疏松症患者一部分人属于骨代谢高转换型 ;雄激素对老年男性骨量的维持起重要作用 ;老年男性维生素D缺乏是骨质疏松症发生的重要基础
Objective To understand the characteristics of bone mineral density and biochemical markers of bone metabolism in elderly men with osteoporosis. Methods The bone mineral density (BMD), bone mineral content (BMC), blood and urine biochemical parameters of lumbar spine were measured in 30 elderly men with osteoporosis and compared with the control group. Results The BMD and BMC in osteoporosis group were significantly lower than those in control group (21.6% and 25%, respectively). Serum alkaline phosphatase (ALP) and C-terminal calcium (BGP) were significantly higher than those of the control group, up by 254% and 22.2% respectively. The ratio of urinary hydroxyproline to creatinine (HOP / Cr) and collagen type I N-terminal peptide The ratio (INTX / Cr) was significantly higher than that of the control group, which increased by 22.6% and 22.3% respectively. The level of serum T in OP group was significantly lower than that in the control group. Serum levels of 25-hydroxyvitamin D3 (25OH D3) in the two groups were all within the normal lower limit or lower than the normal level. Conclusions Lumbar spine (L2 ~ 4) BMD and BMC are the main basis for the diagnosis of osteoporosis in males. Some of the elderly patients with osteoporosis belong to the high turnover bone metabolism. Androgen plays an important role in the maintenance of bone mass in the elderly. Vitamin D deficiency in older men is an important basis for the development of osteoporosis