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目的:探讨平均红细胞体积在筛查孕妇地中海贫血中的临床应用及意义。方法:选取中山市中医院2006～2010年5 000例开展地中海贫血筛查的孕妇,观察平均红细胞体积在筛查中的检测率,并参照基因诊断得出该指标的特异性。结果:依据平均红细胞体积参数指标,5 000例孕妇地中海贫血筛查后检出468例,检出率为9.36%。460例得到确诊,特异性为98.29%。结论:平均红细胞体积在筛查孕妇地中海贫血中具有积极的临床意义,能提高产前检查和孕期体检中疾病检出率,减少重型地贫儿的出生率、降低围生儿病死率,减少孕妇并发症。
Objective: To investigate the clinical application and significance of mean corpuscular volume in the screening of pregnant women with thalassemia. Methods: A total of 5 000 pregnant women who carried out thalassemia screening in Zhongshan Hospital of Traditional Chinese Medicine from 2006 to 2010 were enrolled in this study. The detection rate of average erythrocyte volume during screening was observed. The specificity of this index was obtained with reference to genetic diagnosis. Results: Based on the average volume index of erythrocyte, 468 cases of thalassemia were detected in 5 000 pregnant women, the detection rate was 9.36%. 460 cases were diagnosed, specificity was 98.29%. Conclusion: The average volume of erythrocytes has a positive clinical significance in the screening of pregnant women with thalassemia. It can improve the detection rate of prenatal examination and pregnancy during physical examination, reduce the birth rate of severe geriatric children, reduce perinatal mortality and reduce the incidence of pregnant women disease.