论文部分内容阅读
目的探讨胃肠道间质瘤的临床表现,病理形态特征,免疫组化及治疗方法。方法对资料完整、病理诊断明确的24例胃肠道间质瘤进行回顾性分析。结果光镜下组织学形态表现为两种基本的细胞类型,梭形细胞和上皮样细胞。24例GIST免疫组化中CD117阳性22例(92%),CD34阳性表达19例(79%),vim均表达阳性,SMA.S-100均有少数病例呈阳性表达,提示肿瘤细胞向平滑肌或神经方向分化。结论胃肠道间质瘤的诊断依赖于病理组织形态及免疫组化;外科手术是治疗GIST的首选方法。
Objective To investigate the clinical manifestations, pathological features, immunohistochemistry and treatment of gastrointestinal stromal tumors. Methods Retrospective analysis was performed on 24 cases of gastrointestinal stromal tumors with complete data and clear pathological diagnosis. Results Histopathology showed two basic cell types, spindle cells and epithelioid cells under light microscopy. The positive expression of CD117 in 22 cases (92%) and the positive expression of CD34 in 24 cases of GIST (79%) were positive in vim and few in SMA.S-100, which indicated that tumor cells were expressed in smooth muscle or Neural differentiation. Conclusion The diagnosis of gastrointestinal stromal tumors depends on the histopathology and immunohistochemistry. Surgery is the first choice for the treatment of GIST.