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目的:复制小鼠哮喘模型,并进行激素干预治疗来制作激素依赖性哮喘小鼠模型,在撤减激素过程中,以五紫三黄方干预治疗,观察其对激素依赖性哮喘小鼠模型支气管和肺组织形态学的影响。方法:小鼠雌雄各半共120只,随机分为:空白组、模型组、泼尼松对照组、五紫三黄方低剂量组、中剂量组、高剂量组,每组20只。利用卵蛋白(OVA)复制小鼠哮喘模型,并进行激素干预治疗来制作激素依赖性哮喘小鼠模型,在撤减激素过程中,以五紫三黄方干预治疗,观察小鼠模型支气管和肺组织形态学的影响。结果:五紫三黄方不仅能明显减轻小鼠激素依赖性哮喘气道炎性细胞的浸润,而且能明显改善小鼠哮喘气道的重塑。
OBJECTIVE: To replicate mouse model of asthma and steroid-induced steroid-induced asthma model in mouse model of asthma. During the process of withdrawal of hormone, Wuzishuanghuang prescription was used to treat the asthmatic mouse models of steroid-dependent asthma And lung histomorphology. Methods: A total of 120 male and female mice were randomly divided into three groups: the blank group, the model group, the prednisone control group, the Wusiganghuangfang low dose group, the middle dose group, and the high dose group, 20 rats in each group. Mouse ovalbumin (OVA) replication model of asthma and hormone intervention in the manufacture of hormone-dependent asthma mouse model, in the process of withdrawal of hormones, the intervention of five purple Sanhuang prescription, the mouse model of bronchial and lung Effect of histomorphology. Results: WZSF could not only significantly reduce the infiltration of airway inflammatory cells in mice with hormone - dependent asthma, but also significantly improve the airway remodeling in asthmatic mice.