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目的探讨参芪扶正注射液联合化疗对晚期胃癌患者临床疗效和免疫功能的影响。方法将84例晚期胃癌患者随机分为两组,每组42例,对照组单用化疗方案治疗,观察组在此基础上加用参芪扶正注射液治疗,比较两组治疗前后的临床疗效、免疫功能影响及不良反应发生率等。结果观察组总有效率为45.2%,对照组总有效率为42.9%,两组比较差异无统计学意义(P>0.05);观察组治疗后白细胞介素-12(IL-12)和肿瘤坏死因子-α(TNF-α)水平分别为(0.1663±0.0523)μg/L和(0.2129±0.0055)μg/L,较治疗前升高;对照组治疗后IL-12和TNF-α分别为(0.1233±0.0497)μg/L和(0.1885±0.0063)μg/L,较治疗前降低,两组化疗后比较差异有统计学意义(P<0.05);观察组患者的主要不良反应发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论参芪扶正注射液联合化疗对晚期胃癌患者效果显著,降低化疗方案所致不良反应,改善患者的生活质量,且具有较好的免疫调节作用,值得临床进一步推广和应用。
Objective To investigate the effect of Shenqi Fuzheng injection combined with chemotherapy on clinical efficacy and immune function in patients with advanced gastric cancer. Methods Eighty-four patients with advanced gastric cancer were randomly divided into two groups, 42 cases in each group. The control group was treated with chemotherapy alone. The observation group was treated with Shenqi Fuzheng injection on the basis of the above results. The clinical curative effect was compared between the two groups before and after treatment. Immune function and the incidence of adverse reactions. Results The total effective rate was 45.2% in the observation group and 42.9% in the control group, with no significant difference between the two groups (P> 0.05). After treatment, the levels of interleukin-12 (IL-12) and tumor necrosis The levels of TNF-α were (0.1663 ± 0.0523) μg / L and (0.2129 ± 0.0055) μg / L, respectively, which were higher than those before treatment. The levels of IL-12 and TNF- ± 0.0497) μg / L and (0.1885 ± 0.0063) μg / L, respectively, which were lower than those before treatment. The difference between the two groups after chemotherapy was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control Group, the difference between the two groups was statistically significant (P <0.05). Conclusion Shenqi Fuzheng injection combined with chemotherapy has significant effect on patients with advanced gastric cancer, reducing adverse reactions caused by chemotherapy regimen, improving patients’ quality of life, and has good immunomodulatory effect, worth further promotion and application in clinic.