作者曾证实,给照射小鼠注入某些能抑制前列腺素不同合成阶段的药物,对造血具有刺激作用,能增加白细胞数,骨髓有核细胞数和内源性CFU—S数以及外源性CFU—S数。为了探索这种刺激造血的作用机理,本实验观察了消炎痛对小鼠照后骨髓和造血干细胞恢复动力学的影响。实验用850只(CBA和C5781杂交)F_1雄性小鼠。供体小鼠受~(60)Co—γ线照射(6戈瑞,0.1戈瑞/秒),照后立即和5天内,给消炎痛(6mg/kg)灌胃,每天1次。照后不同时间(从1小时到15天)处死部分供体小鼠,用1根股骨的骨髓细胞悬液输给事先8戈瑞照射、内源性集落形成能力完全被抑制的受体 The authors have confirmed that injecting certain drugs that can inhibit the different synthesis stages of prostaglandins into irradiated mice has a stimulatory effect on hematopoiesis, can increase the number of white blood cells, bone marrow nucleated cells and endogenous CFU-S numbers, and exogenous CFU. - S number. In order to explore this mechanism of action to stimulate hematopoiesis, this experiment observed the effect of indomethacin on the recovery kinetics of bone marrow and hematopoietic stem cells after irradiation in mice. 850 F1 (CBA and C5781 hybrid) F1 male mice were used in the experiment. The donor mice were irradiated with 60 Co-γ rays (6 Gy, 0.1 Gy/s), and indomethacin (6 mg/kg) was intragastrically administered once a day for 5 days. After sacrifice, some donor mice were sacrificed at different times (from 1 hour to 15 days), and one bone marrow cell suspension of the femur was used for the recipients who had previously received 8 Gy irradiation and whose endogenous colony formation capacity was completely inhibited.