目的：分析自身抗原５２ｋＤＲｏ／ＳＳＡ的序列结构，预测其抗原位点。方法：将自身抗原５２ｋＤＲｏ／ＳＳＡ的氨基酸序列输入“蛋白质结构预测”软件包，分析蛋白质分子亲水性、表面可及性、柔性，并模拟其二级结构，预测其主要抗原位点。结果：自身抗原５２ｋＤＲｏ／ＳＳＡ是多抗原位点，其氨基酸序列中１２０～１３０、３００～３２０、３６０～３８０位间抗原性较强。结论：确定５２ｋＤＲｏ／ＳＳＡ的抗原优势表位，为研究抗原抗体间相互作用及其疾病机制打下基础。 Objective: To analyze the sequence structure of 52kDRo / SSA autoantigen and predict its antigenic site. Methods: The amino acid sequence of 52kDRo / SSA was input into the software package of “Protein Structure Prediction” to analyze the hydrophilicity, surface accessibility and flexibility of protein molecules and to simulate their secondary structure and predict the major antigenic sites. Results: The autoantigen 52kDRo / SSA was a multi-antigenic site with a strong antigenicity of 120-130,300-320 and 360- 380 in its amino acid sequence. Conclusion: The dominant epitope of 52kDRo / SSA antigen was determined, which laid the foundation for the study of the interaction between antigen and antibody and its disease mechanism.