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应用ＲＴ－ＰＣＲ方法，观察３８例子宫内膜癌和１６例癌周内膜组织中ｍｄｍ２基因表达及其与子宫内膜癌浸润和淋巴结转移的关系。结果表明：①癌组织中的ｍｄｍ２基因的表达值明显高于癌周内膜组织；②有肌层或血管浸润的子宫内膜癌ｍｄｍ２基因表达值高于无浸润者；③有淋巴结转移者ｍｄｍ２基因表达值也高于无淋巴结转移者；④不同的肿瘤部位及不同年龄组的ｍｄｍ２基因表达值差异无显著性。研究提示ｍｄｍ２基因的表达在子宫内膜癌的浸润和转移中起重要作用。
RT-PCR was used to observe the expression of mdm2 gene in 38 cases of endometrial carcinoma and 16 cases of endometrial carcinoma and its relationship with endometrial carcinoma infiltration and lymph node metastasis. The results showed that: 1 The expression of mdm2 gene in cancer tissue was significantly higher than that in the endometrial tissue; 2 The mdm2 gene expression in endometrial carcinoma with muscular or vascular infiltration was higher than that in non-invasive; 3 mdm2 with lymph node metastasis Gene expression values were also higher than those without lymph node metastases; 4 There was no significant difference in mdm2 gene expression values between different tumor sites and different age groups. Studies suggest that the expression of mdm2 gene plays an important role in the invasion and metastasis of endometrial cancer.