论文部分内容阅读
目的:观察新生儿血浆中神经节苷脂动态变化,评价其对新生儿生长发育的影响。方法:应用改良间苯二酚盐酸微量法测定血浆中总神经节苷脂结合的唾液酸含量。结果:血浆总神经节苷脂结合的唾液酸含量在出生时最低,为(7.80±0.79)nmoL/ml,14 d达高峰,为(16.25±1.44)nmoL/ml,与出生时相比,显著增高,P<0.01。1岁时为(12.22±1.19)nmol/ml,与日龄14 d相比。显著减低,P<0.01;与出生时相比,明显增高,P<0.01。日龄14 d后随日龄增加,血浆总神经节苷脂结合的唾液酸含量逐渐减低(Y=15.36-0.007X+eps,r=-0.53,P<0.01)。结论:新生儿血浆中神经节苷脂水平至少在新生儿期可以反映中枢神经系统的发育与成熟。
OBJECTIVE: To observe the dynamic changes of gangliosides in the plasma of newborn infants and to evaluate their effects on the growth and development of newborn infants. Methods: The content of total ganglioside - bound sialic acid in plasma was determined by a modified trace of resorcinol hydrochloride. Results: The total sialic acid content in plasma was lowest at birth (7.80 ± 0.79) nmoL / ml and reached the peak at 14 days (16.25 ± 1.44) nmoL / ml, which was significantly higher than that at birth , P <0.01.1 years old (12.22 ± 1.19) nmol / ml, compared with 14 days of age. P <0.01; Compared with the time of birth, it was significantly higher (P <0.01). After 14 days of age, the total sialic acid binding of sialic acid decreased gradually with the increase of age (Y = 15.36-0.007X + eps, r = -0.53, P <0.01). CONCLUSIONS: Neonatal ganglioside levels in the plasma reflect at least in the neonatal period central nervous system development and maturation.