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目的:了解我院急性肾功能衰竭的临床表现和危险因素,提高药物相关性肾衰竭的预防水平。方法:回顾性分析我院2007年8月～2009年4月27例致急性肾衰竭的主要药物、临床表现和危险因素。结果:27例药物所致急性肾功能衰竭中,>60岁的患者8例占29.62%,男5例,女3例。引起急性肾损害相关的主要药物为非甾体类抗炎药(11例次,28.2%)、中草药(9例次,23.0%)、头孢菌素类(8例次,20.5%)。27例患者中有基础性疾病的15例,其中患高血压的9例次,肾脏疾病2例次,其他8例次。结论:临床用药应避免肾毒药同时使用,有基础疾病的患者要慎用肾毒性药物,药物使用过程中应密切监测肾脏功能,出现药物性急性肾功能衰竭时,应尽早停药,并及时治疗。
Objective: To understand the clinical manifestations and risk factors of acute renal failure in our hospital and to improve the prevention of drug-related renal failure. Methods: A retrospective analysis of our hospital from August 2007 to April 2009 27 cases of acute renal failure caused by the main drug, clinical manifestations and risk factors. Results: In the 27 cases of acute renal failure caused by drugs, 8 cases accounted for 29.62%, 5 males and 3 females> 60 years old. The main drugs related to acute renal damage were non-steroidal anti-inflammatory drugs (11 cases, 28.2%), Chinese herbal medicine (9 cases, 23.0%) and cephalosporins (8 cases, 20.5%). Among the 27 patients, 15 had underlying diseases, of which 9 were hypertensive, 2 were renal, and 8 were other. Conclusion: The clinical use of nephrotoxic drugs should be avoided at the same time. Nephrotoxic drugs should be used with caution in patients with underlying diseases. During the course of drug use, renal function should be closely monitored. In case of acute renal failure, drug withdrawal should be stopped as soon as possible and treated promptly .