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目的了解膳食纤维对术后结肠癌患者的临床治疗效果,探究其对结肠癌患者术后免疫功能及炎性反应的影响。方法采用前瞻性随机对照研究,选取病理诊断为结肠癌并且行结肠癌根治术的患者60例,其中膳食纤维生态肠内营养组(试验组)30例,生态肠内营养组(对照组)30例。分别于术前第1天、术后第2天、术后第7天清晨空腹抽取外周静脉血,检测血T淋巴细胞亚群(CD3+,CD4+,CD8+)和血清免疫球蛋白(IgA,IgG,IgM)等免疫指标,肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)等炎症反应指标。结果各时间点两组间的CD3+、CD8+、CD4+/CD8+、IgM水平差异无统计学意义(P>0.05),而在术后第7天,试验组CD4+、IgA、IgG水平高于对照组,差异有统计学意义(P<0.05);试验组TNF-α、IL-6水平低于对照组,差异有统计学意义(P<0.05)。结论在结肠癌患者中,术后早期给予膳食纤维可提高患者机体免疫功能、减轻炎性反应。
Objective To understand the clinical effect of dietary fiber on postoperative colon cancer patients and explore its effect on postoperative immune function and inflammatory response in patients with colon cancer. Methods A prospective randomized controlled study was performed in 60 patients with pathological diagnosis of colon cancer and undergoing radical resection of colon cancer. Among them, there were 30 cases of dietary fiber enteral nutrition group (experimental group), 30 cases of ecological enteral nutrition group (control group) example. Peripheral venous blood was collected on the first day before operation, on the second day after operation and on the seventh day after operation. Serum T lymphocyte subsets (CD3 +, CD4 +, CD8 +) and serum immunoglobulins (IgA, IgG, IgM), inflammatory cytokines such as TNF-α, IL-6 and PCT. Results There was no significant difference in the levels of CD3 +, CD8 +, CD4 + / CD8 + and IgM between the two groups at all time points (P> 0.05). On the 7th day after operation, the levels of CD4 +, IgA and IgG in the experimental group were higher than those in the control group The difference was statistically significant (P <0.05). The levels of TNF-α and IL-6 in the experimental group were lower than those in the control group (P <0.05). Conclusion In patients with colon cancer, early postoperative dietary fiber can improve the body’s immune function and reduce inflammatory reaction.