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目的初步探讨氩氦刀联合放疗治疗非小细胞肺癌的局部疗效。方法 2 0 0 1年 1 1月至 2 0 0 2年 7月治疗 5例局部晚期非小细胞肺癌 ,中位年龄 6 7岁 ;周围型 4例 ,中央型 1例 ,原发肿瘤最长径为 6～ 1 0cm ,KPS3R 70。先采用氩氦冷冻经皮穿刺治疗。 1～ 2周后开始放疗 ,TD6 5～ 75Gy/ 6 .5～ 7.5w。氩氦刀治疗后 1～ 2周评价其疗效。氩氦刀 +放疗疗效 (WHO标准 )在疗程结束后评价。结果 1例CR ,4例PR ,总有效率为 1 0 0 %。并发症 :2例血痰 ,1例术中渗血 ,对症支持治疗后愈。随访 3～ 1 8月 ,所有患者切口处无肿瘤种植 ,治疗的第一例随访 1 8个月继续存活。结论巨大原发病灶非小细胞肺癌采用氩氦刀结合放疗是一种有效、微创、可耐受的治疗方法
Objective To investigate the curative effect of argon-helium knife combined with radiotherapy in the treatment of non-small cell lung cancer. Methods From January 2001 to July 2002, 5 patients with locally advanced non-small cell lung cancer were treated. The median age was 67 years. There were 4 cases of peripheral type and 1 case of central type. The longest diameter of primary tumor 6 ~ 10cm, KPS3R 70. First use of argon helium cryo-percutaneous puncture treatment. 1 to 2 weeks after the start of radiotherapy, TD6 5 ~ 75Gy / 6 .5 ~ 7.5w. Argon-helium knife 1 to 2 weeks after treatment evaluation of its efficacy. Argon-helium + radiotherapy (WHO standard) after the end of treatment evaluation. Results 1 case of CR, 4 cases of PR, the total effective rate was 100%. Complications: 2 cases of bloody sputum, 1 case of intraoperative bleeding, symptomatic and supportive treatment after healing. All cases were followed up from March to August. All patients had no tumor implantation at the incision. The first case of follow-up was 18 months of follow-up. Conclusion The huge primary non-small cell lung cancer with argon-helium knife combined with radiotherapy is an effective, minimally invasive and tolerable treatment