肥胖－呼吸困难－嗜睡综合征是一少见疾病，在一个家系中祖孙三代均患此病者更少见，笔者遇到一家系三代３例患者，报告如下。先证者，郑某，男，５６岁，已婚。因呼吸困难、嗜睡８年，加重２月于１９９３年４月２３日入院。患者８年前开始饮食量大增，体重迅速增加，并出现嗜 Obesity - Dyspnea - Somnolence Syndrome is a rare disease, in a pedigree, three generations of the ancestors and grandchildren are more rare, I met a family of three generations of three patients, the report is as follows. Proof, Jeong, male, 56 years old, married. Due to dyspnea, lethargy for 8 years, increased in February on April 23, 1993 admission. 8 years ago, patients began to increase their diet, body weight increased rapidly, and appear addicted