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目的:观察分析左旋氨氯地平片联合辛伐他汀片对高血压合并高胆固醇血症的临床疗效及用药安全性。方法:选择本院家庭病床轻、中度高血压合并高胆固醇血症(总胆固醇(TC)≥6.6mmol/L)的患者,治疗观察6个月。前3个月,每日服用左旋氨氯地平片2.5mg,控制脂肪摄入,增加体育锻炼,后3个月在原方法基础上,每日增加辛伐他汀片20mg。治疗期间,记录治疗前、治疗3个月及治疗6个月后的血压、血脂系列及相关肝肾功能检查指标。结果:3个月后患者收缩压、舒张压稳定下降,血脂指标变化不大。6个月后收缩压较3个月后有所下降,舒张压无明显变化,总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C),载指蛋白B100(apoB100)均较3个月后显著降低;高密度脂蛋白胆固醇(HDL-C)有所升高,均具有显著性差异。结论:高血压合并高胆固醇血症选择左旋氨氯地平片2.5mg/d,辛伐他汀片20mg/d治疗,疗效确切,安全性好。
Objective: To observe and analyze the clinical efficacy and medication safety of levamlodipine tablets and simvastatin tablets in patients with hypertension and hypercholesterolemia. Methods: Patients with mild to moderate family history of hypertension and hypercholesterolemia (total cholesterol (TC) ≥6.6mmol / L) were selected and treated for 6 months. The first 3 months, taking daily levamlodipine tablets 2.5mg, control fat intake, increase physical activity, 3 months after the original method, based on the daily increase of simvastatin tablets 20mg. During treatment, record before treatment, treatment of 3 months and 6 months after treatment of blood pressure, blood lipid series and related indicators of liver and kidney function tests. Results: After 3 months, the systolic blood pressure and diastolic blood pressure decreased steadily, while the blood lipid index did not change much. After 6 months, systolic blood pressure decreased slightly after 3 months and diastolic blood pressure did not change significantly. The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and carrier protein B100 (apoB100) Significantly decreased; high-density lipoprotein cholesterol (HDL-C) increased, with significant differences. Conclusion: L-amlodipine 2.5mg / d and simvastatin 20mg / d are the best choice for hypertension combined with hypercholesterolemia. The curative effect is good and the safety is good.