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目的观察参麦联合环磷腺苷葡胺对冠心病心力衰竭患者心功能的影响,分析其实际临床效果。方法将周口市第二人民医院收治的冠心病心力衰竭患者共92例随机分成研究组和对照组,每组46例。对照组给予常规治疗,研究组在常规治疗基础上给予参麦联合环磷腺苷葡胺治疗,疗程均为14 d。比较两组患者治疗后总有效率、两组治疗前后NYHA心功能分级和血浆BNP水平变化。结果研究组总有效率为95.65%,对照组为76.09%,两组比较差异有统计学意义(P<0.05);治疗前后NYHA心功能分级情况显示,研究组的心功能明显改善,研究组患者血浆脑利钠肽水平下降程度明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论参麦联合环磷腺苷葡胺治疗冠心病心力衰竭患者,能明显提高患者的治疗有效率,治疗效果更为显著,患者心功能得到改善。
Objective To observe the effect of shenmai combined with cyclic adenosine monophosphate on heart function in patients with coronary heart disease and to analyze its clinical effect. Methods A total of 92 patients with coronary heart disease and heart failure admitted to the Second People’s Hospital of Zhoukou City were randomly divided into study group and control group with 46 cases in each group. The control group was given routine treatment. The study group was treated with Shenmai combined with cAMP for 14 days on the basis of routine treatment. The total effective rate was compared between the two groups after treatment, NYHA functional class and plasma BNP level before and after treatment in both groups. Results The total effective rate was 95.65% in the study group and 76.09% in the control group, the difference between the two groups was statistically significant (P <0.05). Before and after NYHA function classification, the cardiac function of the study group was significantly improved. Plasma brain natriuretic peptide levels were significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Shenmai combined with cAMP treatment of heart failure patients with coronary heart disease, can significantly improve the patient’s treatment efficiency, the treatment effect is more significant, patients with improved cardiac function.