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目的观察比较不同血管扩张药物治疗急性心力衰竭的临床效果。方法选取医院收治的急性心力衰竭患者120例为研究对象,采用随机数字法分为A组(乌拉地尔组)、B组(硝酸甘油组)和C组(硝普钠组),每组40例。观察3组患者治疗后的总有效率和血浆BNP含量变化情况。结果治疗后,B组、C组总有效率为90.0%、92.5%,高于A组的75.0%(P<0.05);B组、C组总有效率比较差异无统计学意义(P>0.05)。治疗后,3组血浆BNP含量均低于治疗前,B组、C组血浆BNP含量高于A组(P<0.01或P<0.05)。结论血管扩张药物治疗急性心力衰竭的临床疗效显著,硝普钠在治疗过程中效果较好,在临床治疗中可为医师提供更多的用药选择。
Objective To compare the clinical effects of different vasodilators in the treatment of acute heart failure. Methods A total of 120 patients with acute heart failure admitted to the hospital were enrolled in this study. Patients were randomly divided into A group (Urapidil group), B group (Nitroglycerin group) and C group (Sodium nitroprusside group), 40 example. The total effective rate and plasma BNP level in the three groups were observed. Results After treatment, the total effective rate in group B and group C was 90.0% and 92.5%, respectively, which was higher than that in group A (75.0%, P <0.05). There was no significant difference in total effective rate between group B and group C (P> 0.05 ). After treatment, plasma BNP levels in three groups were lower than those before treatment, while plasma BNP levels in groups B and C were higher than those in group A (P <0.01 or P <0.05). Conclusion The clinical effect of vasodilator drugs in treating acute heart failure is significant. Sodium nitroprusside is better in the course of treatment and provides more choices for doctors in clinical treatment.