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目的分析试管婴儿双胎与自然受孕双胎的母婴结局。方法收集2009年1月至2014年4月在北京大学人民医院定期随诊并分娩、孕周≥28周的双胎产妇共418例,其中试管婴儿双胎产妇(IVF组)235例,自然受孕双胎产妇(NC组)183例,对所有产妇的年龄、妊娠期合并症、分娩方式、产时并发症、新生儿出生体重、新生儿出生缺陷及围产期结局等临床资料进行统计学分析比较。结果 IVF组产妇平均年龄、高龄初产、妊娠期糖尿病、前置胎盘及产后出血发生率高于NC组(P<0.05);IVF组双胎输血发生率显著低于NC组(P<0.05);两组新生儿在出生体重、出生缺陷发生率、围产儿结局等方面比较差异均无统计学意义(P>0.05)。结论与自然妊娠双胎相比,试管婴儿双胎妊娠不增加围产儿并发症与出生缺陷的风险,但IVF组母亲平均年龄大,高龄初产比例高,妊娠期糖尿病、前置胎盘、产后出血发生率高,因此试管婴儿双胎妊娠的产妇在妊娠期间需加强孕期保健。
Objective To analyze the maternal and infant outcome of in vitro fertilized twins and spontaneously conceived twins. METHODS: A total of 418 pregnant women with twin pregnancies (≥28 weeks gestation) who were regularly followed up and delivered at Peking University People’s Hospital from January 2009 to April 2014 were enrolled. Among them, 235 were twin test-tube twins (IVF) A total of 183 twin mothers (NC group) were enrolled in this study. The clinical data of all maternal age, gestational complications, mode of delivery, complications during delivery, neonatal birth weight, neonatal birth defects and perinatal outcome were statistically analyzed Compare Results The incidence of twins in IVF group was significantly lower than that in NC group (P <0.05). The average incidence of preterm birth, gestational diabetes mellitus, placenta previa and postpartum hemorrhage in IVF group were higher than those in NC group (P <0.05) There was no significant difference in birth weight, birth defect rate and perinatal outcome between the two groups (P> 0.05). CONCLUSIONS: In-vitro twin pregnancies did not increase the risk of perinatal complications and birth defects compared with those of spontaneous pregnancies. However, the IVF group had a higher average age of mothers, a higher proportion of early primipara, gestational diabetes mellitus, placenta previa, postpartum hemorrhage High incidence, so test-tube twin pregnancy twins during pregnancy need to strengthen the health care during pregnancy.