论文部分内容阅读
目的研究大豆异黄酮胶囊作为保健食品的食用安全性。方法采用急性毒性试验、小鼠骨髓微核试验、小鼠精子畸形试验、Ames试验和30天喂养试验的结果进行评价。结果雌雄小鼠经口最大耐受剂量(MTD)均大于20.0g/kg体重,属无毒级。Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验三项遗传毒性试验结果均为阴性。30天喂养试验未显示明显毒性。结论大豆异黄酮胶囊属于安全性保健食品。
Objective To study the safety of soy isoflavone capsules as health food. Methods The acute toxicity test, mouse bone marrow micronucleus test, mouse sperm abnormality test, Ames test and 30-day feeding test were used for evaluation. Results Male and female mice oral maximum tolerated dose (MTD) were greater than 20.0g / kg body weight, is non-toxic grade. Ames test, mouse bone marrow micronucleus test, mouse sperm abnormality test three genotoxicity test results were negative. The 30-day feeding test did not show significant toxicity. Conclusion Soy isoflavone capsules are safe and health food.