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目的制备服用方便,稳定性好的制霉素分散片。方法通过筛选崩解剂,采用粉末直接压片工艺制备制霉素分散片,以崩解时限、混悬性等因素为指标,通过正交实验对处方进行筛选。结果优选处方中崩解剂为微晶纤维素30%,可压性淀粉7%,交联聚维酮5%。对优选处方的实验表明:崩解时限小于3 min:分散均匀性和混悬性较好。结论优选处方制备的制霉素分散片达到了分散片的质量要求。
Objective To prepare nystatin dispersible tablets with convenient and good stability. Methods Through the screening of disintegrant, the powder was prepared by direct tabletting process of nystatin dispersible tablets, disintegration time, suspension and other factors as an indicator, the orthogonal test for screening. Results The preferred prescription of the disintegrant is microcrystalline cellulose 30%, compressible starch 7%, crospovidone 5%. Experiments on preferred prescriptions showed that the disintegration time was less than 3 min: good dispersibility and suspension. Conclusion The best preparation of nystatin dispersible tablets to achieve the quality requirements of the dispersible tablets.