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RIG-Ⅰ样受体(RLRs)是一类新发现的模式识别受体,能够识别细胞质中的病毒RNA,在抗病毒天然免疫中起着重要的作用。RIG-I样受体包括视黄酸诱导基因I(RIG-1)、黑色素瘤分化相关基因5(MDA5)以及LGP2。在国家自然科学基金重点项目资助下,中国科学院水生生物研究所鱼类免疫学与寄生虫学学科组和苏格兰鱼类免疫研究中心进行合作研究,揭示了RIG-I样受体MDA5和LGP2在低等脊椎动物中的功能。与哺乳动物MDA5和LGP2相同,鱼类的MDA5和LGP2也能结合病毒双链RNA成分。然而与哺乳类的LGP2调控MDA5信号通路的功能不同,鱼类MDA5
RIG-Ⅰ-like receptors (RLRs) are newly discovered pattern recognition receptors that recognize viral RNA in the cytoplasm and play an important role in antiviral innate immunity. RIG-I-like receptors include retinoic acid-induced gene I (RIG-I), melanoma differentiation-related gene 5 (MDA5), and LGP2. Supported by the National Natural Science Foundation of China funded by the National Institute of Hydrobiology Institute of Fish Immunology and Parasitology and Scottish Fish Immunology Research Center collaborative research revealed that RIG-I-like receptors MDA5 and LGP2 in the low Other vertebrates in the function. Like mammalian MDA5 and LGP2, fish MDA5 and LGP2 also bind to viral double-stranded RNA components. However, unlike mammalian LGP2, the function of the MDA5 signaling pathway is regulated by fish MDA5