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目的：评价国产洛美沙星（ｌｏｍｅｆｌｏｘａｃｉｎ）治疗细菌性感染的有效性和安全性。方法：随机对照开放试验。结果：随机对照组７６例，用氧氟沙星（ｏｆｌｏｘａｃｉｎ）对照，其中两组痊愈率和有效率分别是６６．７％，６４．９％和８９．７％，８９．２％；细菌阳性率是８２．１％与８６．５％；细菌清除率是９０．６％和９３．８％；不良反应发生率是５．１％和５．４％。以上结果经统计学处理，无显著差异（Ｐ＞０．０５）。开放试验组８０例，其痊愈率和有效率分别是６７．５％与８６．３％；细菌阳性率是８５％；细菌清除率８８．２％。不良反应发生率５．０％。全部临床分离菌株纸片法药敏试验及ＭＩＣ结果表明两药作用相似，但明显优于氨苄青霉素、头孢拉定和庆大霉素。结论：洛美沙星可作为临床上常见致病菌所致感染的选择用药。
Objective: To evaluate the efficacy and safety of domestic lomefloxacin in the treatment of bacterial infections. Methods: Randomized controlled open trials. Results: Randomized controlled group of 76 patients were treated with ofloxacin. The cure rate and effective rate of the two groups were 66.7%, 64.9% and 89.7%, 89.2% respectively. The positive bacteria Rates were 82.1% and 86.5%; bacterial clearance rates were 90.6% and 93.8%; adverse reactions were 5.1% and 5.4% respectively. The above results by statistical analysis, no significant difference (P> 0.05). The open test group 80 cases, the cure rate and effective rate were 67.5% and 86.3% respectively; the positive rate of bacteria was 85%; the bacterial clearance rate was 88.2%. The incidence of adverse reactions 5.0%. All the clinical isolates of drug susceptibility test paper and MIC results show that the two drugs similar, but significantly better than ampicillin, cephradine and gentamicin. Conclusion: Lomefloxacin can be used as the choice of common pathogenic bacteria infection.