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为观察不同剂量的牛磺酸侧脑室灌注对家兔体温的影响。方法:实验将新西兰家兔分为4组,分别静脉注射ET和NS后侧脑室灌注牛磺酸和人工脑脊液,测定家兔的直肠温度。结果:家兔侧脑室灌注小剂量牛磺酸(003mmol/kg)后,可以明显降低ET引起的体温上升,但对正常体温没有影响;用大剂量牛磺酸(006mmol/kg)灌注侧脑室,不仅完全阻断家兔的ET性发热,而且可以使家兔的正常体温降低。结论:牛磺酸脑室灌注具有降低家兔ET性发热和正常体温的作用,其降温效应与给药剂量有关。
To observe the different doses of taurine lateral ventricle on rabbit body temperature. Methods: New Zealand rabbits were divided into 4 groups. After intracerebroventricular injection of taurine and artificial cerebrospinal fluid after intravenous injection of ET and NS respectively, the rectal temperature of rabbits was measured. Results: After intravenous injection of taurine (003 mmol / kg) into the lateral ventricle of rabbits, the increase of body temperature in ET-induced rabbits could be obviously reduced, but no effect on body temperature was observed. High dose taurine (0.06 mmol / Perfusion of the lateral ventricle, not only completely blocked the ET fever in rabbits, but also can reduce the normal body temperature in rabbits. Conclusion: Taurine intraventricular infusion has the effect of reducing ET fever and normal body temperature in rabbits, and its cooling effect is related to the dosage.