论文部分内容阅读
目的:研究清胆胶囊的抗炎、镇痛、清热、利胆作用。方法:采用巴豆油致小鼠耳肿胀模型,考察清胆胶囊抗炎作用;采用醋酸致小鼠扭体模型和热刺激致疼痛模型,考察清胆胶囊镇痛作用;采用酵母菌致家兔发热模型,考察清胆胶囊清热作用;采用家兔胆固醇结石模型,考察清胆胶囊利胆作用。结果:清胆胶囊对巴豆油所致小鼠耳肿胀具有消肿作用,能够明显减少醋酸所致疼痛小鼠的扭体次数,增加热刺激引起的小鼠痛阈,对酵母菌致家兔发热具有明显的解热作用,可抑制家兔胆固醇结石的形成。结论:清胆胶囊具有抗炎、镇痛、清热、利胆作用。
Objective: To study the anti-inflammatory, analgesic, heat-clearing and gallbladder effects of Qingdan capsules. METHODS: The model of mouse ear swelling induced by croton oil was used to investigate the anti-inflammatory effects of Qingdan capsules. The analgesic effect of Qingdan capsules was investigated by the acetic acid-induced writhing model of mice and the pain model induced by heat stimulation. The yeast fever was induced in rabbits. The model was used to investigate the heat-clearing effect of Qingdan capsules. The rabbit gallstone cholesterol model was used to investigate the effects of Qingdan capsules. Results: Qingdan capsule had swelling effect on mouse ear swelling caused by croton oil, which can significantly reduce the number of writhing of pain mice caused by acetic acid, increase the pain threshold of mice caused by thermal stimulation, and cause fever for rabbits caused by yeast. With obvious antipyretic effects, it can inhibit the formation of cholesterol stones in rabbits. Conclusion: Qingdan Capsule has anti-inflammatory, analgesic, heat-clearing and gallbladder effects.