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酒精性肝病(alcoholic liver disease,ALD)是由于长期大量饮酒导致的中毒性肝损害,包括酒精性脂肪肝、酒精性肝炎、酒精性肝硬化。研究发现,核因子κB(NF-κB)作为一种多功能的细胞转录因子,在肝脏炎症、纤维化及肝细胞再生、凋亡等病理生理中起着重要作用。NF-κB通过调控细胞激酶、趋化因子、生长因子、细胞黏附因子及早期反应的蛋白质分子基因的转录而参与炎症和免疫反应、某些疾病的病理产生、急性期反应、细胞增殖和细胞凋亡及对病毒感染的反应等。由于广泛参与许多基因的转录调控及细胞的凋亡调控和转化,故NF-κB在许多疾病中高度表达。
Alcoholic liver disease (ALD) is a toxic liver injury caused by long-term heavy drinking, including alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis. The study found that nuclear factor κB (NF-κB) as a multi-functional cellular transcription factor plays an important role in the pathophysiology of liver inflammation, fibrosis and hepatocyte regeneration and apoptosis. NF-κB is involved in inflammation and immune response by regulating the transcription of cellular kinases, chemokines, growth factors, cell adhesion molecules, and early-reacted protein molecular genes, pathologies of certain diseases, acute phase responses, cell proliferation and apoptosis Death and reaction to the virus infection. Due to its extensive involvement in the transcriptional regulation of many genes and the regulation and transformation of apoptosis in cells, NF-κB is highly expressed in many diseases.