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用双抗体夹心酶联免疫吸附试验检测１５例慢性粒细胞白血病（ＣＭＬ）患者脑脊液（ＣＳＦ）可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平。结果显示：ＣＭＬ急变期患者脑脊液ｓＩＬ－２Ｒ水平显著高于正常对照，ＣＭＬ慢性期及加速期与正常对照组间均无显著差异。合并中枢神经系统白血病（ＣＮＳ－Ｌ）患者ＣＳＦ中ｓＩＬ－２Ｒ明显高于ＬＣＮＳ－Ｌ者，治疗达缓解后渐降至正常范围。合并ＣＮＳ－Ｌ者ｓＩＬ－２Ｒ水平升高与ＣＳＦ中白血病细胞浸润呈正相关。我们认为ｓＩＬ－２Ｒ可作为ＣＮＳ－Ｌ诊断的参考指标之一，并可用于监测病情，观察疗效。
The levels of soluble interleukin 2 receptor (sIL-2R) in cerebrospinal fluid (CSF) of 15 patients with chronic myelogenous leukemia (CML) were detected by double antibody sandwich enzyme-linked immunosorbent assay. The results showed that the level of sIL-2R in cerebrospinal fluid of patients with CML blast crisis was significantly higher than that of normal controls, and there was no significant difference between chronic phase and accelerated phase of CML and normal controls. In patients with central nervous system leukemia (CNS-L), sIL-2R in CSF was significantly higher than that in LCNS-L, and the treatment gradually decreased to normal range after remission. Increased levels of sIL-2R in patients with CNS-L were positively correlated with leukemia cell infiltration in CSF. We believe that sIL-2R can be used as one of the reference indicators for the diagnosis of CNS-L and can be used to monitor the condition and observe the efficacy.