论文部分内容阅读
为探讨大腹皮对大鼠胃电节律失常的影响及其机制 ,将 30只健康成年Wistar大鼠随机分为 3组 :①正常对照组 ;②模型组 ;③大腹皮 +模型组。通过胃电记录仪记录并分析各组慢波频率、慢波频率变异系数及异常节律指数 ,同时对各组大鼠胃窦肌间神经丛胆碱能及氮能神经进行组化染色。结果发现 ,模型组大鼠胃慢波频率变异系数及异常节律指数明显高于对照组 (P <0 0 1) ,应用大腹皮后模型组大鼠胃慢波频率变异系数及异常节律指数与对照组差异无显性意义 (P >0 0 5 ) ;模型组大鼠胃窦肌间神经丛胆碱能神经密度明显低于对照组 (P <0 0 1) ,氮能神经密度明显高于对照组 (P <0 0 5 ) ,应用大腹皮后大鼠胃窦肌间神经丛胆碱能和氮能神经密度明显减少 ,与对照组比较差异无显性意义 (P >0 0 5 )。提示 ,大腹皮对大鼠胃电节律失常具有调节作用 ,其机制可能与增加胃窦肌间神经丛胆碱能神经分布及减少氮能神经分布有关。
To investigate the effect and mechanism of gastrodialysis on gastric motility disorders in rats, 30 healthy adult Wistar rats were randomly divided into 3 groups: 1 normal control group; 2 model group; and 3 large abdominal cortex + model group. The frequency of slow wave, the coefficient of variation of slow wave frequency, and the index of aberrant rhythm were recorded and analyzed by electrogastrogram. At the same time, cholinergic and nitrergic nerves in the antrum myenteric plexus of each group were stained. The results showed that the frequency of slow-wave frequency variation and aberrant rhythm index in the model group were significantly higher than those in the control group (P < 0.01). The frequency of the slow-wave frequency variation and the abnormal rhythm index in the rat model group were significantly higher than those in the control group. There was no significant difference in the control group (P > 0.05). The cholinergic nerve density in the antrum myenteric plexus in the model group was significantly lower than that in the control group (P < 0.01), and the nerve density was significantly higher than that in the control group. In the control group (P <0 05), the cholinergic and nitrergic nerve density in the myenteric plexus of the gastric antrum in the rat after the application of the large abdomen was significantly reduced, and there was no significant difference compared with the control group (P > 0 05). . It is suggested that the diarrhea has a regulatory effect on gastric electrical dynamia in rats, and its mechanism may be related to the increase of the distribution of cholinergic nerves in the antrum myenteric plexus and the decrease of nitrogen energy nerve distribution.