论文部分内容阅读
目的分析神经梅毒患者特点和患者性别的差异性。方法回顾性分析31例神经梅毒患者。结果 31例神经梅毒患者包括男17例,女14例。患者初次起病的临床表现包括肢体无力16例(51.6%)、头痛4例(12.9%),头晕2例(6.5%)、癫痫3例(9.7%)、视力下降2例(6.5%)和精神症状4例(12.9%)。核磁共振扫描的结果显示正常5例(16.1%)、脑萎缩3例(9.7%)、脑梗塞11例(35.5%)、脑白质病变8例(25.8%)、脑膜炎3例(9.7%)和脑积水1例(3.2%)。根据性别分成男性与女性两组,结果显示不同性别的年龄、补体C3、补体C4、尿酸、血白细胞等指标存在统计学差异(P<0.05)。经过治疗96.8%(30/31)患者临床症状明显改善,男性(94.1%)与女性(100%)比较治疗效果无明显差异(P>0.05)。结论神经梅毒的临床症状与影像学改变没有特异性,诊断应注意与其它的中枢神经系统疾病进行鉴别。同时,我们亦发现男女性别的神经梅毒患者具有一定的差异。
Objective To analyze the characteristics of patients with neurosyphilis and the gender differences of patients. Methods Retrospective analysis of 31 patients with neurosyphilis. Results 31 cases of neurosyphilis patients including 17 males and 14 females. The clinical manifestations of initial onset included 16 cases (51.6%) with limb weakness, 4 cases (12.9%) with headache, 2 cases with dizziness (6.5%), 3 cases with epilepsy (9.7%) and 2 cases with vision loss Psychiatric symptoms in 4 cases (12.9%). Results of MRI showed normal 5 cases (16.1%), brain atrophy in 3 cases (9.7%), cerebral infarction in 11 cases (35.5%), white matter lesions in 8 cases (25.8%), meningitis in 3 cases And hydrocephalus in 1 case (3.2%). According to sex, male and female were divided into two groups. The results showed that there were significant differences in gender, age, complement C3, complement C4, uric acid and white blood cells (P <0.05). The clinical symptoms of 96.8% (30/31) treated patients were significantly improved. There was no significant difference in the treatment effect between male (94.1%) and female (100%) patients (P> 0.05). Conclusion The clinical symptoms and imaging changes of neurosyphilis are not specific. Diagnosis should be distinguished from other central nervous system diseases. At the same time, we also found some differences between men and women with neurosyphilis.