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目的:观察米非司酮与三苯氧胺合用,续贯以米索前列醇终止早孕的流产效果、流产后出血时间及药物副反应的情况。方法:将自愿选择药物流产(药流)的健康早孕妇女随机分成研究组和对照组。研究组采用米非司酮联合三苯氧胺配伍米索前列醇的方法终止早孕,米非司酮总量150mg,三苯氧胺总量60mg,第4天晨空腹口服米索600μg。对照组采用米非司酮续贯米索前列醇的方法,米非司酮150mg,第1天晨空腹口服,第4天晨空腹口服米索600μg。比较两种方法药流效果。结果:研究组的完全流产率、阴道出血量、药物副作用与对照组相比差异均无统计学意义(P>0.05),而阴道平均出血时间,研究组为(8.4±1.9)天较对照组(10.9±2.1)天明显缩短,差异有统计学意义(P<0.01)。结论:米非司酮联合60mg三苯氧胺配伍米索前列醇终止早孕,可以减少药流后出血时间。
Objective: To observe the combination of mifepristone and tamoxifen, abortion with misoprostol abortion termination of early pregnancy, bleeding time after abortion and side effects of the drug. Methods: Healthy early pregnant women who voluntarily chose medical abortion (drug abortion) were randomly divided into study group and control group. The study group used mifepristone and tamoxifen combined with misoprostol to terminate the pregnancy. The total amount of mifepristone 150mg, tamoxifen total 60mg, the morning of 4 days morning oral misoprostol 600μg. The control group with mifepristone continued misoprostol method, mifepristone 150mg, the first day of fasting oral administration, the first 4 days of morning fasting oral misoprostol 600μg. Compare two methods of medical abortion effect. Results: There was no significant difference in the rate of complete abortion, vaginal bleeding and drug side effects between the two groups (P> 0.05), while the average vaginal bleeding time was (8.4 ± 1.9) days in the study group than in the control group (10.9 ± 2.1) days was significantly shorter, the difference was statistically significant (P <0.01). Conclusion: Mifepristone combined with 60mg tamoxifen and misoprostol to terminate early pregnancy can reduce bleeding time after medical abortion.