Objective:To summarize and critically evaluate the evidence for and against the effectiveness of Eastern-Western integrative medicine(EWIM) for health care compared to Eastern medicine(EM) or Western medicine(WM) alone.Methods:Systematic searches were conducted on five Korean medical databases.Manual searches were also conducted through nine major Korean medical journals.Prospective randomized clinical trials (RCTs) were included if EWIM was tested for any type of conditions compared to EM or WM.Results:There were one hundred forty-one possibly relevant studies were identified,and seven RCTs were included.The risk of bias was high in most studies.The EWIM methods were compared with EM or WM in patients with pain conditions in four studies.These studies showed favorable effects of EWIM on pain reduction in patients with shoulder pain and chronic headache compared with EM,while the other RCTs failed to do so in traffic injury patients.Two studies tested EWIM in patients with Bell’s palsy compared with EM and found acute functional improvement.An RCT comparing EWIM with WM in patients with acne showed a significant difference.Conclusion:The results of our systematic review suggest that there is limited evidence for the superiority of EWIM over EM or WM in the treatment of pain and acute symptom improvement in patients with Bell’s palsy.The evidence from our analysis was limited from the low number of RCTs included and the high risk of bias.Future RCTs appear to be warranted. Objective: To summarize and critically evaluate the evidence for and against the effectiveness of Eastern-Western integrative medicine (EWIM) for health care compared to Eastern medicine (EM) or Western medicine (WM) alone. Methods: Systematic searches were conducted on five Korean Medical databases.Manual searches were also conducted throughout nine major Korean medical journals. Prospective randomized clinical trials (RCTs) were included if EWIM was tested for any type of conditions compared to EM or WM. Results: There were one hundred forty-one may relevant studies were identified, and seven RCTs were included. The risk of bias was high in most studies. The EWIM methods were compared with EM or WM in patients with pain conditions in four studies. sesetions showed favor effects of EWIM on pain reduction in patients with shoulder pain and chronic headache compared with EM, while the other RCTs failed to do so in traffic injury patients. Two studies tested EWIM in patients with Bell’s palsy compared with EM and found acute functional improvement. An RCT comparing EWIM with WM in patients with acne showed a significant difference. Conlusion: The results of our systematic review suggest that there is limited evidence for the superiority of EWIM over EM or WM in the treatment of pain and acute symptom improvement in patients with Bell’s palsy. the evidence from our analysis was limited from the low number of RCTs included and the high risk of bias. Future RCTs appear to be warranted.