新抗生素筛选工作经历了几个历史阶段,到今天,从微生物代谢产物中筛选新抗生素的时代是否已经过去,微生物的抗生素资源是否已发掘完了。对这些问题医药界早就存在着一些不同看法,对我国抗生素事业的发展不无影响。当前在制定我国科技发展规划的时候,有必要进一步讨论这些问题,以求得一致的看法。一、微生物仍然是新抗生素的重要来源半合成抗生素研究已经取得了巨大成就,也是新抗筛选的重要途径。但是,自微生物代谢产物中筛选新抗生素的工作并未被半合成取代,相反,近几年来也有了很大进 New antibiotic screening has gone through several historic stages. To this day, whether the age of screening new antibiotics from microbial metabolites is over and whether the antibiotic resources of the microorganisms have been unearthed. The pharmaceutical industry has long had some different opinions on these issues and has had no effect on the development of the cause of antibiotics in our country. At present, when formulating the development plan for science and technology in our country, it is necessary to discuss these issues further in order to reach a consensus. First, the micro-organisms is still an important source of new antibiotics Semi-synthetic antibiotics have made great achievements in research, but also an important new anti-screening approach. However, the selection of new antibiotics from microbial metabolites has not been partially replaced by semisynthesis. On the contrary, there has also been a great progress in recent years