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目的:探讨艾灸“神阙”穴对长期力竭运动大鼠免疫系统的影响.方法:将30只SD雄性大鼠随机分为空白组、模型组、艾灸组,每组1 0只.除空白组外,采用反复游泳实验制造长期力竭模型.艾灸组大鼠造模后“神阙”穴施温和灸1 5 min,隔日1次,共治疗1 0次.记录每次力竭时间、检测第1 0次力竭运动24 h后血清IgA、IgG、IgM、ACP含量及观察脾组织形态变化.采用免疫比浊法检测IgA含量,采用ELISA法检测IgG、IgM、ACP含量.结果:艾灸组总体力竭时间较模型组长,但从第5次以后各时间点的差异有统计学意义(P＜0.01).模型组较空白组血清IgG和IgM含量明显降低(均P＜0.01),血清ACP含量明显升高(P＜0.01),脾组织形态受到破坏;艾灸组较模型组血清-IgG和IgM含量明显升高(均P＜0.01),血清ACP含量明显降低(P＜0.01),脾组织形态得以修复.结论:艾灸神阙穴可以提高长期疲劳机体的免疫球蛋白(IgG、IgA、IgM)的含量,降低ACP含量,修复被破坏的脾组织.“,”Objective To explore the effect of moxibustion at "Shénquè”(神阙 CV 8) on the immune system of rats taking long-term exhaustive exercise.Method Thirty male SD rats were randomly divided into blank group,model group and moxibustion group with 10 rats in each group.Except the rats in blank group,all the rats were established into long-term exhaustive models through swimming again and again.Mild moxibustion at CV 8 for 15 min was carried out in the rats in moxibustion group after modeling.The treatment was conducted once every other day,and treatment for 10 times was needed.The exhaustive duration for each time was recorded,the levels of serum IgA,IgG,IgM and ACP were detected 24 h after the 10th exhaustive exercise,and the histomorphological changes of spleen were observed.Immunoturbidimetry was adopted for detecting the IgA level,and ELISA method was used for detecting the levels of IgG,IgM and ACE Results The common exhaustive duration in moxibustion group was longer than that in model group,however,the time difference was statistically significant after the 5th exhaustive exercise (P＜0.01).The levels of serum IgG and IgM in model group were lower than that in blank group (all P＜0.01),and the serum ACP level in model group was higher than that in blank group (P＜0.01),indicating that the splenic histomorphology was damaged.The levels of serum IgG and IgM in moxibustion group were higher than that in model group (all P＜0.01),and the serum ACP level in moxibustion group was lower than that in model group,showing that the splenic histomorphology was repaired.Conclusion Moxibustion at CV 8 can improve the levels of immunoglobulin (IgG,IgA,IgM) of tired body for a long time,decrease the ACP level,and repair the damaged spleen tissues.