Ten coumarin derivatives containing (E)-methyl 2-(methoxyimino)-2-phenylacetate were synthesized and bioassayed. The compounds were identified by IR, 1H NMR and elemental analyses. The test results indicated that compound 5j (R1 is methyl and R2 is n-C6H13) was the optimal structure in this paper with good fungicidal activity against CDM (85%) at 6.25 mg/L concentration.